Southern California is where the story of Devils in the Desert takes place. The specific town in which Will Tobias, Deputy Jackson, and the other locals of the story are from is never named though.
The town is a small, rancher’s community type town surrounded by desert and ranches. Will Tobias is the acting sheriff of the community when the story takes place, with Daniel Jackson as his deputy. The reader is given the impression that this town is fairly small in size since personal matters seem to be known amongst the people of the town, and they are also very unified when it comes to emergency matters (I.E the inclusion of Deputy Jackson’s son on the whole investigation.)
The climate in the comics is fairly true to that of what the climate of southern California really is, arid and desert like.